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. 2021 May 2;142(1):159–177. doi: 10.1007/s00401-021-02317-z

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© The Author(s) 2021

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Fig. 6 — TIR-MAPT RNA expression in the brains of AD patients. a Measurement of TIR-MAPT, b total MAPT and c TIR-MAPT/total MAPT ratio of RNA levels by RT-qPCR of non-demented (n = 8) and AD hippocampal samples (n = 16) classified according to their Braak stage (Braak II n = 3, Braak III n = 2, Braak V n = 7 and Braak VI n = 4), and healthy vs. AD patients. Graphs show means and SE. One-way ANOVA and Dunnett’s multiple comparisons test were performed and statistical significance of each group with respect to non-demented control individuals was given. For comparisons between non-demented individuals and AD patients as groups, p values were calculated using a T test (*p ≤ 0.05; ***p ≤ 0.001, ^†p = 0,078)