Skip to main content
. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Free Radic Biol Med. 2021 Jan 12;170:150–178. doi: 10.1016/j.freeradbiomed.2020.12.452

Figure 7. Pathways involved in increased MiD49/51 induced mitochondrial fission, cell proliferation and apoptosis resistance in A) PAH and B) cancer.

Figure 7.

A. The expression of MiD49 and MiD51, are increased in PAH due to the downregulation of their regulatory microRNA, miR-34a-3p. This increase in MiD expression drives pathological mitochondrial fission by sequestering activated Drp1 to the outer mitochondrial membrane (OMM), cell proliferation and apoptosis resistance via PDGFR-α/β-Ras-Raf-Erk pathway.

B. In cancer, downregulation of miR-34a-3p leads to MiD upregulation which in turn drives mitochondrial fission by sequestering activated Drp1 to the outer mitochondrial membrane (OMM), cell proliferation and apoptosis resistance via Akt-mTOR-S6K axis.