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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Free Radic Biol Med. 2021 Jan 12;170:150–178. doi: 10.1016/j.freeradbiomed.2020.12.452

Figure 9. Therapeutic effects of Mfn2 in PAH.

Figure 9.

A. Overexpression of Mfn2 by adenoviral mediated gene transfer (Adv-Mfn2) induces mitochondrial fusion in control PASMC and PAH PASMC. Cells were the loaded with the potentiometric dye TMRM (red) and imaged with confocal microscope to assess the mitochondrial network structure. Scale bar: 50mm.

B. Representative CT angiogram showing pruning of small pulmonary arteries in Su/Hx rats, which can be reversed by augmenting Mfn2. Su/Hx rats were treated either with Ad-GFP or Ad-Mfn2. Compared to the control, Su/Hx rats exhibit decreased percentage of small pulmonary arteries whilst Ad-Mfn2 treatment increased the percentage of small pulmonary arteries.

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