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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Free Radic Biol Med. 2021 Jan 12;170:150–178. doi: 10.1016/j.freeradbiomed.2020.12.452

Table 1.

Summary of studies on miRNAs that target PKM2 in pulmonary hypertension and cancer cells and associated mechanistic pathway.

MiRNA Species Cell Type Mechanism
miR-1, miR-133b [381], miR-124, miR-137 & miR-340 [382] Human Colorectal cancer PTBP1/PKM2 pathway
miR-124 [152, 153, 383] Human PAH-blood outgrowth endothelial cells miR-124/PTBP1/PKM2 pathway
Rat PAH-fibroblasts
Bovine Colorectal cancer
miR-133a & −133b [384] Human Tongue squamous cell carcinoma Directly targets PKM mRNA
miR-122 [385] Human Hepatocellular carcinoma Directly targets PKM2 mRNA
miR-148a & miR-326 [386] Human Thyroid cancer Directly targets PKM2 mRNA
miR-148a & miR-152 [387] Human Breast cancer Directly targets PKM2 mRNA
miR-152 [388] Human Breast cancer miR-152/β-catenin/PKM2 pathway
miR-372 [389] Human Liver cancer miR-372/YB-1/β-catenin/LEF/T CF 4-PKM2 pathway
miR-491–5p [390], miR-1294 [203] Human Osteosarcoma Directly targets PKM2 mRNA
miR-361–5p [391] Human Prostate cancer miR-361–5p/Sp1/PKM2 pathway
miR-let-7a [392] Human Cervical cancer Directly targets PKM2 mRNA