. Author manuscript; available in PMC: 2022 Jun 1.

Published in final edited form as: Transplant Cell Ther. 2021 Feb 25;27(6):476.e1–476.e7. doi: 10.1016/j.jtct.2021.02.018

Table 1.

Transfusion sensitized DLA-identical HCT with ²¹¹At-anti-CD45 mAb and 9.2Gy TBI

Dog ID	H824	H734	H773	H848	H851	H845	H940
At-211 activity (mCi/kg)	0.188	0.206	0.211	0.302	0.302	0.304	0.387
TNC/kg (× 10^s)	5.4	1.33	8.31	7.45	4.22	6.27	6.52
CD34+/kg (10⁶)	4.26	0.35	5.48	1.91	1.73	1.97	2.28
Maximum chimerism (% MNC)	100	42	100	100	100	100	100
Final chimerism (% MNC)	100	0	100	100	100	100	100
Rejection	NO	YES	NO	NO	NO	NO	NO
Survival days	367	21	60	44	368	367	28
Cause of death (euthanized)	End of Study	Rejection	Liver toxicity	Pneumonia	End of Study	End of Study	Severe gastroenteritis

A total of 7 dogs received ²¹¹At-anti-CD45 mAb. Six of seven dogs achieved 100% donor chimerism. H 734 rejected the graft.

DLA: dog leukocyte antigen; HCT: hematopoietic cell transplantation; TBI: total body irradiation; TNC: total nucleated cell count; MNC: mononuclear cell; GVHD: graft versus host disease.