. Author manuscript; available in PMC: 2022 Jun 1.

Published in final edited form as: Transplant Cell Ther. 2021 Feb 25;27(6):476.e1–476.e7. doi: 10.1016/j.jtct.2021.02.018

Table 2.

Transfusion sensitized DLA-identical HCT with ²¹¹At-anti-CD45 mAb and 7.5Gy TBI

Dog ID	H911	H920	H923	H935	H933	H929
At-211 activity (mCi/kg)	0.243	0.435	0.439	0.486	0.501	0.528
TNC/kg (× 10⁸)	4.50	5.31	4.66	3.97	2.77	6.51
CD34+/kg (10⁶)	1.22	1.32	2.38	2.91	0.99	3.50
Maximum chimerism (% MNC)	51	77.7	51.7	0.5	100	4.7
Final Chimerism (% MNC)	0	68.6	13.6	0	100	0
Rejection	YES	NO	NO	YES	NO	YES
Survival days	70	28	44	27	364	32
Cause of death (euthanized)	Rejection	Sepsis	Bone marrow aplasia	Rejection	End of Study	Rejection

A total of 6 dogs received 7.5 Gy TBI as dose de-escalation.

DLA: dog leukocyte antigen; HCT: hematopoietic cell transplantation; TBI: total body irradiation; TNC: total nucleated cell count; MNC: mononuclear cell.