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. Author manuscript; available in PMC: 2022 Jun 1.
Published in final edited form as: Transplant Cell Ther. 2021 Feb 25;27(6):476.e1–476.e7. doi: 10.1016/j.jtct.2021.02.018

Table 3.

Comparison with prior studies*

50 mL Blood transfusions, days Conditioning Dogs (n) Graft rejection (%)
None[26,27] 9.2Gy TBI 62 2
Marrow donor day-24, day-17, day-10 [4,26] 9.2Gy TBI 27 100
Marrow donor day-24, day-17, day-10 9.2Gy TBI with 211At-anti-CD45 mAb 7 14
*

In our well-established canine model, following 9.2Gy TBI conditioning, only 2% (1/62) of un-transfused dogs rejected the marrow grafts from their DLA-identical littermate donors. However, 100% (27/27) of the dogs pretreated with three unirradiated transfusions from their respective DLA-identical marrow donors rejected their grafts. 211At-anti-CD45 mAb in combination with 9.2Gy TBI is successful in abrogating graft. Rejection was only 14% (1/7) of dogs in the pre-sensitization model. n: number; TBI: total body irradiation.