Table 1.
Baseline Characteristics
| BM | Related PBSC | Unrelated PBSC | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Characteristic | Fresh | Cryo | P | Fresh | Cryo | P | Fresh | Cryo | P |
| No. of patients | 456 | 154 | 3030 | 1051 | 2028 | 678 | |||
| Median age at transplant (y) | 32.5 (0.6–79.8) | 34.7 (0.4–75.1) | .74 | 56.8 (3.7–76) | 56.9 (7.6–77.7) | .52 | 54.7 (0.9–83.4) | 54.9 (0.9–77.9) | .93 |
| Male Sex (%) | 235 (52) | 80 (52) | .73 | 1767 (58) | 645 (61) | .03 | 1220 (60) | 394 (58) | .21 |
| Race (%) | .29 | .03 | .007 | ||||||
| Caucasian | 374 (82) | 120 (78) | 2440 (81) | 871 (83) | 1795 (89) | 581 (86) | |||
| African-American | 21 (5) | 10 (6) | 161 (5) | 60 (6) | 72 (4) | 32 (5) | |||
| Other | 22 (4) | 10 (7) | 228 (7) | 60 (6) | 70 (3) | 31 (5) | |||
| Missing | 39 (9) | 14 (9) | 201 (7) | 60 (6) | 91 (4) | 34 (5) | |||
| KPS >=90, n(%) | 289 (63) | 102 (66) | .57 | 1688 (56) | 612 (58) | .16 | 1114 (55) | 353 (52) | .24 |
| HCT-CI | .39 | .04 | .97 | ||||||
| 0 | 163 (36) | 54 (35) | 675 (22) | 193 (18) | 384 (19) | 133 (20) | |||
| 1–2 | 139 (30) | 42 (27) | 872 (29) | 305 (29) | 574 (28) | 193 (28) | |||
| 3+ | 154 (34) | 58 (38) | 1483 (49) | 553 (53) | 1070 (53) | 352 (52) | |||
| Primary disease | .95 | .66 | .87 | ||||||
| AML | 201 (44) | 64 (42) | 1230 (41) | 454 (43) | 906 (45) | 291 (43) | |||
| ALL | 115 (25) | 43 (28) | 461 (15) | 151 (14) | 316 (16) | 111 (16) | |||
| CML | 23 (5) | 8 (5) | 82 (3) | 24 (2) | 72 (4) | 24 (4) | |||
| MDS/MPD | 82 (18) | 29 (19) | 855 (28) | 274 (26) | 447 (22) | 160 (24) | |||
| Other acute leukemia | 14 (3) | 5 (3) | 31 (1) | 14 (1) | 32 (2) | 10 (1) | |||
| NHL | 13 (3) | 3 (2) | 304 (10) | 113 (11) | 208 (10) | 69 (10) | |||
| Hodgkin lymphoma | 8 (2) | 2 (1) | 67 (2) | 21 (2) | 47 (2) | 13 (2) | |||
| DRI, n(%) | |||||||||
| Adult | .92 | .74 | .58 | ||||||
| Low | 25 (5) | 8 (5) | 196 (6) | 72 (7) | 163 (8) | 56 (8) | |||
| Intermediate | 149 (33) | 49 (32) | 1734 (57) | 582 (55) | 997 (49) | 335 (49) | |||
| High | 69 (15) | 21 (14) | 762 (25) | 277 (26) | 507 (25) | 172 (25) | |||
| Very high | 13 (3) | 5 (3) | 104 (3) | 36 (3) | 123 (6) | 42 (6) | |||
| Pediatric (adult definition) | .93 | .76 | .08 | ||||||
| Low | 5 (1) | 2 (1) | 1 (0) | 1 (0) | 11 (1) | 2 (0) | |||
| Intermediate | 70 (15) | 24 (16) | 13 (0) | 2 (0) | 23 (1) | 5 (1) | |||
| High | 67 (15) | 25 (16) | 15 (0) | 5 (0) | 12 (1) | 1 (0) | |||
| Very high | 0 | 0 | 1 (0) | 0 | 2 (0) | 1 (0) | |||
HCT-CI indicate Hematopoietic Cell Transplantation Comorbidity index; AML, acute myelogenous leukemia; ALL, acute lymphoblastic leukemia; CML, chronic myelogenous leukemia; MDS/MPD, myelodysplastic disease/myeloproliferative disease; NHL, non-Hodgkin’s lymphoma