Indication	Catecholamine-resistant systemic hypotension Refractory pulmonary hypertension not responsive to inhaled nitric oxide
Dose	Acute crisis: 1 mg/kg/dose q 6 h Maintenance: 1 mg/kg/day in divided doses Severe PPHN not due to infection – 4 mg/kg/dose x 1 followed by 1 mg/kg q 6h x 4 doses followed by maintenance
Precautions	Occult infection – fungal, viral (herpes simplex, CMV etc.,), bacterial can be exacerbated with steroid therapy
Contraindications	Known or suspected infection
Class of Recommendation	Class IIb – Usefulness/efficacy is less well established by evidence/opinion. May be considered
Level of Evidence	C – Consensus of opinion of the experts and/or small studies, retrospective studies, registries