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. Author manuscript; available in PMC: 2021 Jul 1.
Published in final edited form as: Arch Dis Child Fetal Neonatal Ed. 2021 Jan 21;106(4):446–455. doi: 10.1136/archdischild-2020-319705
Indication Hypotension without decreased cardiac function, hypoxemia
Dose 0.05 to 0.5 mcg/kg/min – occasionally may need up to 1 mcg/kg/min in PPHN with severe hypotension24
Precautions Increased systemic vasoconstriction may decrease mesenteric perfusion and tolerance/safety of feeding
Watch for extravasation – (extravasation will need therapy with Phentolamine)
Contraindications Significant cardiac dysfunction unless using with an inotropic agent as well
Class of Recommendation Class IIa – Weight of evidence/opinion is in favor of usefulness/efficacy. Should be considered
Level of Evidence C – Consensus of opinion of the experts and/or small studies, retrospective studies, registries