Table 2.

Cox regression survival analysis of propensity-matched patients.

		Univariable					Multivariable
		n	HR	Lower	Upper	Sig	HR	Lower	Upper	Sig
Age		156	1.03	1.01	1.05	0.017	1.02	1.00	1.04	0.055
Sex	Male	95	ref	-	-	-
	Female	61	0.95	0.56	1.62	0.846
Race	White	127	ref	-	-	-
	African American	21	1.37	0.69	2.72	0.367
	Other/Unknown	8	0.64	0.16	2.64	0.536
Surgical Procedure	Local Excision	78	ref	-	-	-	ref	-	-	-
	APR	78	1.27	0.76	2.13	0.360	1.11	0.54	2.27	0.782
Charlson-Deyo Score	0	127	ref	-	-	-	ref	-	-	-
	1	17	1.76	0.88	3.52	0.110	1.81	0.82	3.99	0.139
	≥2	12	1.79	0.80	4.00	0.157	1.69	0.74	3.91	0.216
Tumor Location	Anus	47	ref	-	-	-	ref	-	-	-
	Anal Canal	46	1.63	0.79	3.38	0.187	1.61	0.75	3.46	0.225
	Overlapping sites of Anus/Anal Canal/Rectum	63	1.83	0.95	3.54	0.072	1.83	0.90	3.71	0.096
Tumor Size		130	1.00	1.00	1.00	0.938
Clinical T Stage	cT2	58	ref	-	-	-	ref	-	-	-
	cT3	98	1.93	1.08	3.46	0.027	2.44	1.26	4.75	0.009
Grade	Well Differentiated	17	ref	-	-	-	ref	-	-	-
	Moderately Differentiated	80	3.04	0.93	9.99	0.067	2.08	0.61	7.07	0.241
	Poorly/Undifferentiated	26	3.70	1.01	13.52	0.048	3.73	1.01	13.81	0.049
	Unknown	33	3.38	0.98	11.70	0.054	2.54	0.72	8.99	0.150
Lymphovascular Invasion	Absent	55	ref	-	-	-
	Present	8	1.31	0.38	4.56	0.673
	Unknown	93	0.55	0.65	2.25	0.546
Margin Status	R0	101	ref	-	-	-
	R1/R2	40	1.34	0.76	2.35	0.309
	Unknown	15	0.69	0.21	2.23	0.533
CRT Sequence	Adjuvant CRT	88	ref	-	-	-	ref	-	-	-
	Neoadjuvant CRT	62	1.92	1.09	3.39	0.024	1.63	0.76	3.51	0.210