Table 2:
Multivariable Adjusted Associations of AMH with Hormonal Contraceptive Usea, Cumulative Duration of Use, Age at Start, and Time Since Last Use Compared to Never Usersb
| N | Estimate of % change in AMH (95% CI) | |
|---|---|---|
| Status of hormonal contraceptive use | ||
| Never | 232 | Reference |
| Former | 951 | −4.4% (−16.3%, 9.0%) |
| Current | 460 | −25.2% (−35.3%, −13.6%) |
| Total duration of hormonal contraceptive use (ever users) | ||
| Current and cumulative use <1 year | 20 | −33.5% (−56.1%, 0.8%) |
| Current and cumulative use 1–3 years | 92 | −21.1% (−36.9%, −1.4%) |
| Current and cumulative use ≥4 years | 328 | −26.9% (−37.4%, −14.7%) |
| Former and cumulative use <1 year | 183 | −2.2% (−18.1%, 16.8%) |
| Former and cumulative use 1–3 years | 354 | −3.4% (−17.0%, 12.5%) |
| Former and cumulative use ≥4 years | 414 | −6.5% (−19.5%, 8.6%) |
| Age at start of hormonal contraceptive (ever users) | ||
| <15 years | 145 | −12.2% (−27.5%, 6.3%) |
| 15–20 years | 968 | −11.3% (−22.3%, 1.3%) |
| 21–25 years | 236 | −14.0% (−27.3%, 1.6%) |
| ≥26 years | 47 | −19.7% (−39.9%, 7.2%) |
| Time since last use of hormonal contraceptive (ever users) | ||
| Current | 460 | −26.1% (−36.2%, −14.5%) |
| Within last year | 124 | −5.1% (−22.2%, 15.8%) |
| > 1 year ago | 827 | −4.4% (−16.4%, 9.4%) |
a
Includes users of COC, ring, DMPA, implant, patch and LNG-IUD
b
The reference group is “never users” (n= 232)
The multivariable model adjusted for age, age2, BMI, and reported histories of PCOS, abnormal menstrual bleeding, thyroid condition, and seeking care for difficulty conceiving.