Table 1.
Demographics, comorbidities, and clinical data of 321 patients with COVID-19 stratified according to disease severity.
| Total cohort (n = 321) | Mild disease (n = 56) | Moderate disease (n = 180) | Severe disease (n = 85) | p valuec | |
|---|---|---|---|---|---|
| Age in years, median (IQR) | 63 (52–77) | 48 (40–60) | 62 (52–75) | 75 (63–84) | < 0.001 |
| Age ≥ 70 (%) | 118 (36.8) | 8 (14.3) | 58 (32.2) | 52 (61.2) | < 0.001 |
| Male sex (%) | 169 (52.6) | 29 (51.8) | 90 (50.0) | 50 (58.8) | 0.40 |
| Chronic underlying diseases (%) | |||||
| Arterial hypertension | 150 (46.7) | 16 (28.6) | 80 (44.4) | 54 (63.5) | < 0.001 |
| Diabetes mellitus | 57 (17.8) | 6 (10.7) | 35 (19.4) | 16 (18.8) | 0.31 |
| Chronic lung diseasea | 38 (11.8) | 3 (5.4) | 26 (14.4) | 9 (10.6) | 0.17 |
| Cardiovascular disease | 64 (19.9) | 5 (8.9) | 32 (17.8) | 27 (31.8) | 0.002 |
| Chronic kidney disease | 22 (6.9) | 2 (3.6) | 13 (7.2) | 7 (8.2) | 0.54 |
| Chronic liver disease | 10 (3.1) | 1 (1.8) | 6 (3.3) | 3 (3.5) | 0.82 |
| Cancerb | 25 (7.8) | 5 (8.9) | 9 (5.0) | 11 (12.9) | 0.08 |
| Symptoms (%) | |||||
| Fever | 237 (73.8) | 38 (67.9) | 142 (78.9) | 57 (67.1) | 0.07 |
| Rhinorrhea | 19 (5.9) | 6 (10.7) | 10 (5.6) | 3 (3.5) | 0.20 |
| Odynophagia | 22 (6.9) | 6 (10.7) | 11 (6.1) | 5 (5.9) | 0.45 |
| Myalgias | 70 (21.8) | 13 (23.2) | 37 (20.6) | 20 (23.5) | 0.83 |
| Headache | 57 (17.8) | 11 (19.6) | 30 (16.7) | 16 (18.8) | 0.84 |
| Cough | 216 (67.3) | 40 (71.4) | 128 (71.1) | 48 (56.5) | 0.04 |
| Expectoration | 33 (10.3) | 7 (12.5) | 16 (8.9) | 10 (11.8) | 0.64 |
| Pleuritic chest pain | 14 (4.4) | 3 (5.4) | 9 (5.0) | 2 (2.4) | 0.57 |
| Dyspnea | 147 (45.8) | 19 (33.9) | 75 (41.7) | 53 (62.4) | 0.001 |
| Diarrhea | 52 (16.2) | 12 (21.4) | 33 (18.3) | 7 (8.2) | 0.06 |
| Vomiting | 20 (6.2) | 1 (1.8) | 16 (8.9) | 3 (3.5) | 0.08 |
| Impaired consciousness | 12 (3.7) | 1 (1.8) | 6 (3.3) | 5 (5.9) | 0.42 |
| Days from symptom onset to diagnosis, median (IQR) | 7 (3–10) | 7 (5–12) | 6 (3–10) | 6 (2–10) | 0.35 |
| Infiltrate on chest X-ray (%) | 224 (69.8) | 9 (16.1) | 140 (77.8) | 75 (88.2) | < 0.001 |
| Signs (categorized, %) | |||||
| Temperature > 37.5 °C | 82 (26.9) | 5 (11.1) | 48 (27.0) | 29 (35.4) | 0.01 |
| SBP < 90 mmHg | 7 (2.5) | 1 (2.4) | 4 (2.4) | 2 (2.8) | 0.99 |
| DBP < 60 mmHg | 24 (8.6) | 1 (2.4) | 9 (5.5) | 14 (19.4) | 0.001 |
| Hart rate > 100 bpm | 70 (21.8) | 5 (8.9) | 41 (22.8) | 24 (28.2) | 0.02 |
| Respiratory rate > 20 bpm | 17 (20.0) | 0 (0) | 5 (10.6) | 12 (35.3) | 0.01 |
| SpO2 < 95% | 127 (39.6) | 4 (7.1) | 52 (28.9) | 71 (83.5) | < 0.001 |
aChronic obstructive pulmonary disease, obstructive sleep apnea, or asthma.
bActive solid or hematologic malignant neoplasms.
cAcross all three groups.