Table 2.

Pharmacokinetics of intravenous ITPP administration per cohort.

Cohort (Single dose)	Cmin [mg/L]	Cmax [mg/L]	Tmax [h]	Clast [mg/L]	Tlast [h]	Half life/T0.5 [h]	Elimination rate λz [/h]	AUC [h*mg/L]	AUMC [h2*mg/L]	MRT [h]	CL [L/h]	VSS [L]
1 (1866 mg/m2)	0.0	47.2	6.0	19.2	10.0	1.3	0.5	350.7	1994.7	1.7	4.8	11.0
2 (3732 mg/m2)	0.0	120.6	6.0	55.8	10.0	1.8	0.4	847.4	4925.6	1.8	3.8	10.5
3 (5600 mg/m2)	0.0	153.4	6.0	59.5	10.0	1.4	0.5	1168.7	6445.9	1.5	4.4	9.2
4 (7000 mg/m2)	0.0	228.0	6.0	127.5	10.0	3.3	0.2	1649.5	9421.8	1.7	3.1	12.8
5 (8750 mg/m2)	0.0	257.8	6.0	116.8	10.0	2.1	0.3	1850.5	10396.4	1.6	4.0	11.1
6 (10500 mg/m2)	0.0	313.4	6.0	186.4	10.0	2.6	0.3	2439.2	13886.7	1.7	3.3	11.7
7 (12390 mg/m2)	0.0	353.6	6.0	149.4	10.0	1.7	0.4	2457.2	14095.2	1.7	4.4	11.4
8 (14500 mg/m2)	0.0	439.2	6.0	166.0	10.0	1.8	0.4	2864.1	16280.4	1.7	4.4	11.4

C_min [mg/L] = minimal concentration at start of infusion; C_max [mg/L] = maximum concentration; T_max [h] = time of maximum concentration; C_last [mg/L] = last positive concentration observed; T_last [h] = time of last positive concentration; Half-life / T_0.5 [h] = half-life by lambda z = ln(2)/λz; Elimination rate λz [/h] = lambda z, negative of best fit terminal slope; AUC [h*mg/L] = Area under the curve from 0 to T_last; AUMC [h2*mg/L] = Area under the first moment curve to the T_last; MRT [h] = mean residence time; CL [L/h] = clearance; VSS [L] = volume of distribution at steady state