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. Author manuscript; available in PMC: 2021 Jun 22.
Published in final edited form as: Mov Disord. 2021 Jan 26;36(6):1440–1445. doi: 10.1002/mds.28502

FIG. 1.

FIG. 1.

Climbing fibers (CFs) pathology in the essential tremor (ET) cerebellar cortex. (A–C) Representative images of CFs, labeled by cocaine and amphetamine-regulated transcript (CART) (brown), and Purkinje cells (PCs), labeled by calbindin (red), in a control (A) and three ET cases (B, C). Arrows, CART-labeled CF crossings. Dashed lines, the pial surface of the cerebellar cortex. Scale bar: 25 μm. (D, E) ET cases have CFs crossing more PC somas and PC dendrites in comparison with control cases. (F, G) The number of PC somas or the number of PC dendrites crossed by a CF correlates with tremor severity. Error bars represent the standard deviation.