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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Neuropharmacology. 2021 May 11;192:108599. doi: 10.1016/j.neuropharm.2021.108599

Figure 4. Exendin-4 attenuates fentanyl seeking in rats.

Figure 4.

Rats were pretreated with vehicle or exendin-4 prior to fentanyl and cue-primed reinstatement test sessions. Total active lever responses (A) and total number of infusions (B) were attenuated in rats pretreated with 0.072 and 0.72 nmol/kg exendin-4 versus vehicle (n=13/treatment; *p<0.05, Bonferroni). (C) 24-hour kaolin intake was significantly increased in rats pretreated with 0.72 nmol/kg exendin-4 compared with vehicle (n=16/treatment; *p<0.05, Bonferroni). (D) Cumulative chow intake in rats pretreated with 0.72 nmol/kg exendin-4 were significantly decreased compared to vehicle (n=13/treatment; *p<0.05, Bonferroni). (E) 24-hour water intake was not altered in fentanyl-experienced rats (n=13/treatment) pretreated with exendin-4 during abstinence. (F) Body weight in rats pretreated with 0.72 nmol/kg exendin-4 was significantly decreased compared to vehicle (n=13/treatment; *p<0.05, Bonferroni).