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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Neuropharmacology. 2021 May 11;192:108599. doi: 10.1016/j.neuropharm.2021.108599

Figure 6. Systemic administration of exendin-4 or GEP44 does not reinstate drug-seeking behavior.

Figure 6.

The unique effects of exendin-4 and GEP44 on drug seeking were tested in rats (n=11/treatment) pretreated with vehicle, 0.72 nmol/kg exendin-4, or 2.4 nmol/kg GEP44 prior to extinction test sessions. In the absence of a priming injection of fentanyl and light cues previously paired with fentanyl infusions during the self-administration phase, neither exendin-4 or GEP44 reinstated drug-seeking behavior. There were no effects of either drug on total active lever responses (A) or total number of infusions (B) during reinstatement test sessions.