Table 3.
Summary of all signs and symptoms occurring during or within 4 hours after NK cell infusion that were either definitely, probably or possibly related to the infusion
| Sign/symptom | Grade 1 | Grade 2 | Grade 3 | Grade 4 | Total, n (%) |
|---|---|---|---|---|---|
| Constitutional | |||||
| Chills | 29 | 80 | 1 | - | 110 (84.6%) |
| Fever (no infection) | 17 | 6 | 15 | - | 38 (29.2%) |
| Respiratory | |||||
| Dyspnea | 4 | 3 | 8 | - | 15 (11.5%) |
| Hypoxia | 1 | 4 | 8 | - | 13 (10.0%) |
| Bronchospasm | 0 | 3 | 3 | - | 6 (4.6%) |
| Pneumonitis | 1 | 1 (0.8%) | |||
| Cardiovascular | |||||
| Hypertension | 6 | 16 | 17 | - | 39 (30.0%) |
| Hypotension | 3 | 4 | 2 | 1 | 10 (7.7%) |
| Tachycardia* | - | - | - | - | 2 (1.5%) |
| Chest pain | 1 | 1 (0.8%) | |||
| CNS | |||||
| Headache | 12 | 9 | 8 | 29 (22.3%) | |
| Gastrointestinal | |||||
| Nausea** | - | - | - | - | - |
| Emesis** | - | - | - | - | - |
| Abdominal cramps | - | 1 | - | - | 1 (0.8%) |
| Ascites | 2 | - | - | - | 2 (1.5%) |
| Musculoskeletal | |||||
| Myalgia | 1 | 4 | 1 | - | 6 (4.6%) |
| Skin/subcutaneous | |||||
| Rash | 2 | - | - | - | 2 (1.5%) |
| Other | |||||
| Localized edema | 8 | 4 | - | - | 12 (9.2%) |
| Sweating | 1 | - | - | - | 1 (0.8%) |
| Dry eye | 1 | - | - | - | 1 (0.8%) |
*
Tachycardia was not part of routine reporting for CTCAE; two episodes of tachycardia were noted in the record that were not graded
**
Reports of nausea/vomiting were not graded - anecdotally they appeared to mostly be mild and readily treatable