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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Transl Res. 2021 Mar 9;234:58–73. doi: 10.1016/j.trsl.2021.03.006

Figure 1.

Figure 1.

Conceptual model, illustrating hypothesized bidirectional relationships of sleep deficiency (focus of this review), and other salient factors (pain states, negative mood/stressors, physiological mediators), with opioid craving and/or use.