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. 2021 Jun 21;11:12915. doi: 10.1038/s41598-021-92319-4

Table 2.

Multivariate Cox regression analysis for the associations between BMI change trajectories and hypertension by sex.

BMI change trajectories Case/N Unadjusted modelb Adjusted modelc
HR (95% CI)a p value HR (95% CI)a p value
Male
Loss 139/388 1.10 (0.92–1.31) 0.287 0.74 (0.62–0.89) 0.002
Stable 1064/2795 Ref. Ref.
Moderate gain 1121/2789 1.00 (0.92–1.09) 0.991 1.23 (1.13–1.34) < 0.001
Substantial gain 363/855 1.08 (0.96–1.21) 0.224 1.65 (1.45–1.86) < 0.001
Female
Loss 259/744 1.28 (1.11–1.46)  < 0.001 0.87 (0.75–1.00) 0.053
Stable 1044/3487 Ref Ref
Moderate gain 924/2643 1.03 (0.94–1.12) 0.582 1.28 (1.17–1.40) < 0.001
Substantial gain 224/561 1.24 (1.07–1.43) 0.003 1.83 (1.58–2.12) < 0.001

aHR hazard ration, CI confidence interval.

bUndjusted model is crude model without any covariates.

cAdjusted model adjusted variables including age, survey wave, initial BMI, initial SBP/DBP, change of PA and dietary energy intake, change of smoking and drinking status.