Table 5.
Summary of the healing rate and treatment failure of amniotic membrane transplantation (AMT) in large case series (N > 5 eyes) based on the types of causative microorganisms.
| Authors | Year | Numbers | Complete healing | Healing time (days) | Adverse events |
|---|---|---|---|---|---|
| Bacterial keratitis | |||||
| Altay et al.36 | 2016 | 42 | 42 (100%) | 19 | 0 (0%) |
| Berguiga et al.37 | 2013 | 1 | 1 (100%) | – | 0 (0%) |
| Chen et al.40 | 2002 | 6 | 5 (83%) | 9 | 1 (17%) |
| Eraslan Yusufoglu et al.42 | 2013 | 21 | 21 (100%) | 22 | 0 (0%) |
| Gicquel et al.44 | 2007 | 12 | 12 (100%) | 26 | 0 (0%) |
| Hoffmann et al.45 | 2013 | 3 | 2 (67%) | 31 | 1 (33%) |
| Kim et al.46 | 2001 | 9 | 9 (100%) | – | 0 (0%) |
| Mohan et al.48 | 2014 | 28 | 21 (75%) | – | 7 (25%) |
| Fungal keratitis | |||||
| Chen et al.39 | 2006 | 12 | 11 (92%) | 4–26 | 1 (8%) |
| Eleiwa et al.41 | 2020 | 5 | 5 (100%) | 26 | 0 (0%) |
| Fu et al.43 | 2012 | 35 | 33 (92%) | 14 | 1 (3%) |
| Kim et al.46 | 2001 | 2 | 2 (100%) | – | 0 (0%) |
| Rao et al.49 | 2012 | 21 | 16 (76%) | – | 2 (10%) |
| Xie et al.54 | 2014 | 19 | 8 (42%) | 36 | Not reported |
| Zhang et al.56 | 2010 | 26 | 21 (81%) | – | 2 (8%) |
| Herpetic keratitis | |||||
| Altay et al.36 | 2016 | 42 | 40 (95%) | 19 | 2 (5%) |
| Berguiga et al.37 | 2013 | 4 | 3 (75%) | – | 1 (25%) |
| Eraslan Yusufoglu et al.42 | 2013 | 25 | 22 (88%) | 22 | 3 (12%) |
| Hoffmann et al.45 | 2013 | 5 | 5 (100%) | 21 | 0 (0%) |
| Kim et al.46 | 2001 | 7 | 7 (100%) | – | 0 (0%) |
| Li et al.47 | 2010 | 18 | 18 (100%) | – | 0 (0%) |
| Shi et al.50 | 2007 | 15 | 15 (100%) | 15 | 0 (0%) |
| Spelsberg et al.51 | 2008 | 12 | 9 (75%) | 25 | 3 (25%) |
| Wu et al.53 | 2013 | 18 | 18 (100%) | 17 | 0 (0%) |
| Acanthamoeba keratitis | |||||
| Bourcier et al.38 | 2004 | 6 | 4 (67%) | – | 0 (0%) |
| Kim et al.46 | 2001 | 3 | 3 (100%) | – | 0 (0%) |
| Mixed bacterial and fungal keratitis | |||||
| Chen et al.39 | 2006 | 11 | 9 (82%) | 7–23 | 2 (18%) |
| Mixed bacterial and herpetic keratitis | |||||
| Hoffmann et al.45 | 2013 | 4 | 4 (100%) | 22 | 0 (0%) |