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. Author manuscript; available in PMC: 2021 Jul 1.
Published in final edited form as: J Hepatol. 2021 Feb 9;75(1):34–45. doi: 10.1016/j.jhep.2021.01.043

Fig. 1. CNNM4 is overexpressed in NASH patients and preclinical animal models.

Fig. 1.

(A) Magnesium determination in serum and (B) hepatic levels of CNNM1-4 mRNA in different cohorts of healthy individuals, patients with steatosis and patients with NASH. (C) Levels of Cnnm1-4 mRNA in primary hepatocytes stimulated with MCD medium. (D) Liver immunohistochemical staining and quantification for CNNM4 in a cohort of healthy individuals, patients with steatosis and patients with NASH, as well as mice fed (E) a 0.1% MCDD or (F) a CD-HFD. Scale bar corresponds to 100 μm. *p <0.05, ***p <0.001, and ****p <0.0001 vs. healthy/ctrl/SC diet. CD-HFD, choline-deficient high-fat diet; MCD, methionine and choline deficient; MCDD, MCD diet; NASH, non-alcoholic steatohepatitis; SC diet, regular diet.