Table 2.
CpG sites associated with atopic asthma (at FDR-P < 0.05) in a meta-analysis of data from three cohorts (EVA-PR, Project Viva, and PIAMA)
| CpG | Gene | Chr | Position | EVA-PR | Project Viva | PIAMA | β meta-analysis | P value meta-analysis | FDR_P meta-analysis | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| β | P value | β | P value | β | P value | |||||||
| cg02695349 | STARD3NL | chr7 | 38269241 | 0.0205 | 1.04E-02 | 0.0488 | 1.10E-05 | 0.0138 | 7.44E-02 | 0.0237 | 1.40E-06 | 2.80E-04 |
| cg04990977 | SLC35F4 | chr14 | 58221774 | −0.0478 | 4.67E-06 | −0.0134 | 1.87E-02 | −0.0170 | 2.62E-02 | −0.0199 | 1.66E-06 | 2.80E-04 |
| cg18146152 | TSR3 | chr16 | 1400772 | −0.0042 | 5.24E-01 | 0.0073 | 8.90E-03 | 0.0131 | 5.79E-05 | 0.0084 | 2.62E-05 | 2.93E-03 |
| cg03541903 | CDC42SE2 | chr5 | 130651434 | 0.0071 | 5.39E-01 | 0.0095 | 8.64E-03 | 0.0209 | 1.90E-03 | 0.0117 | 1.24E-04 | 1.05E-02 |
| cg21376795 | KLHL25 | chr15 | 86302121 | 0.0050 | 3.25E-01 | 0.0027 | 4.01E-01 | 0.0154 | 7.41E-06 | 0.0080 | 1.74E-04 | 1.17E-02 |
| cg27178677 | PLCB1 | chr20 | 8834803 | −0.0328 | 3.60E-05 | 0.0028 | 7.65E-01 | −0.0119 | 2.03E-02 | −0.0144 | 2.30E-04 | 1.29E-02 |
| cg17076485 | BUD13 | chr11 | 116580712 | −0.0112 | 1.18E-01 | −0.0014 | 8.88E-01 | −0.0225 | 2.28E-04 | −0.0150 | 4.09E-04 | 1.96E-02 |
| cg17335499 | OR2B3 | chr6 | 29054325 | −0.0179 | 9.49E-03 | −0.0085 | 1.07E-02 | −0.0040 | 2.90E-01 | −0.0078 | 7.54E-04 | 3.13E-02 |
| cg26772788 | GALR1 | chr18 | 75609054 | 0.0042 | 4.81E-01 | 0.0045 | 3.84E-01 | 0.0224 | 3.35E-05 | 0.0106 | 8.39E-04 | 3.13E-02 |
| cg03729152 | TMEM196 | chr7 | 19961027 | 0.0247 | 3.27E-03 | 0.0054 | 2.28E-01 | 0.0148 | 2.00E-02 | 0.0110 | 9.56E-04 | 3.15E-02 |
| cg01039401 | TEAD4 | chr12 | 3070406 | −0.0612 | 1.80E-05 | 0.0036 | 8.14E-01 | −0.0192 | 1.15E-01 | −0.0260 | 1.03E-03 | 3.15E-02 |
| cg16848072 | ANAPC13 | chr3 | 134182665 | 0.0074 | 1.91E-01 | 0.0044 | 1.58E-01 | 0.0100 | 6.30E-03 | 0.0068 | 1.72E-03 | 4.80E-02 |