Skip to main content
. Author manuscript; available in PMC: 2022 Apr 28.
Published in final edited form as: Cytoskeleton (Hoboken). 2021 Apr 28;78(3):77–96. doi: 10.1002/cm.21662

Table 3.

BLAST best-hit search of Chlamydomonas IDA IC/LC/accessary subunits in human genome

BLAST comparisona
Chlamydomonas reinhardtii Homo sapiensb Potential related/associated disease in humans
Actin/DII4/IDA5 ACTG1 (0.0)c, d Various
Centrin/DLE2/VFL2 CETN2 (2e-55) -
FAP120/DII7 N/Ae -
IC140/DIC3/IDA7 WDR63/DNAI3 (6e-55) Occipital encephalocele (Hofmeister et al., 2018)
IC138/DIC4/BOP5 WDR78/DNAI4 (2e-68) -
IC97/DII6/FAP94 CASC1/CFAP94 (2e-11) Pulmonary carcinoma (Galbiati et al., 2006)
LC7a/DLR1/ODA15 DYNLRB2 (1e-40) -
LC7b/DLR2 DYNLRB2 (3e-20) -
LC8/DLL1/FLA14 DYNLL2 (2e-56) -
MOT7 TEX47 (6e-14) Hypothyroidism (Eriksson et al., 2012)
NAP/DII5 N/Af -
p28/DII1/IDA4 DNALI1 (1e-93) -
p38/DII2/FAP146 ZMYND12 (1e-19) -
p44/DII3 TTC29 (2e-13) Asthenoteratospermia/Asthenozoospermia (Liu et al., 2019; Lorès et al., 2019)
TCTEX1/DLT3 DYNLT1 (2e-42) -
TCTEX2b/DLT4 TCTEX1D2/DYNLT2B (5e-35) Jeune asphyxiating thoracic dystrophy (Schmidts et al., 2015)
a

For the presence/absence of the potential homologous DHCs of Chlamydomonas IDAs in humans, see the previous papers (Hom et al., 2011; Kollmar, 2016; Morris et al., 2006). For potential links between human IDA DHCs and diseases, see Section 2-1 in the main text.

b

Blast search using the Chlamydomonas sequences as queries against the Ensembl genome browser 102 human database (http://www.ensembl.org/Homo_sapiens/Info/Index).

c

Gene names and BLAST e-Values are shown in the columns.

d

Letters in bold in human proteins mean that the reciprocal BLAST search against Chlamydomonas Phytozome genome database (v5.5) identified the corresponding dynein subunit as the best hit in Chlamydomonas reinhardtii.

e

Because of the presence of ANK repeats, the exact human orthologue(s) of FAP120 in humans is hard to determine (Ikeda et al., 2009).

f

From the detailed phylogenetic analyses, homologues of NAP/DII5 are only present in algae phylogenetically close to Chlamydomonas (Kato-Minoura et al., 2003; Kato-Minoura et al., 1998).