Table 1.

TRP channels and COVID-19 symptoms.

Symptom	TRP channel(s) involved in the symptom	Reference
Inflammation	TRPV4	[20]
Inflammation	TRPA1	[36]
Stress-related inflammatory processes	TRPM2	[37]
Airway inflammation induced by viral infection	TRPV1	[38, 40]
Pain	TRPV1	[15]
Pain	TRPM2, TRPM3,TRPM8	[39]
Pain	TRPV2, TRPV3, TRPV4, TRPC1, TRPC6	[39]
Fever	TRPM2	[46]
Pulmonary edema	TRPM2, TRPV4, TRPV1, TRPC1, TRPC4, TRPC6	[19]
Ventilator-induced lung injury	TRPV4	[48]
Oxidative stress	TRPV1	[43]
Oxidative stress	TRPA1	[28]
Nitric oxide and ROS production in alveolar macrophages	TRPV4	[49]
Increase in the endothelial permeability of pulmonary blood vessels	TRPC6	[53]
Pulmonary fibrosis	TRPV4, TRPM7	[20, 21]
Cough	TRPA1, TRPV4, TRPV1	[65]
Headache	TRPV1	[71]
Headache	TRPV4	[74]
Headache	TRPA1	[70]
Myalgia	TRPV channels	[13]
Ischemic muscle Myalgia	TRPV1	[76]
Loss of taste	TRPM4, TRPM5	[79]
Loss of smell	TRPM5	[80]
Hearing impairment	TRPV4	[84]
Vomiting	TRPA1	[90]
Nausea	TRPV1	[59]
Loss of appetite	TRPA1	[91]
Loss of appetite	TRPV1	[92]
Cardiac arrhythmia	TRPM4	[96]
Cardiac fibrosis	TRPM7	[21]
Endothelial redox sensors	TRPC3, TRPC4, TRPM2	[97]
Endothelial barrier dysfunction	TRPC1, TRPC4, TRPC6, TRPV4, TRPM2	[97]