Table 8.

Univariate and multivariate cox regression analysis of T1 mapping values for the prediction of MACE in subgroup 3.

	Patients without MACE (N = 24)	Patients with MACE (N = 8)	HR (95% CI)	P-value
Univariate cox regression analysis
Major SCD risk factor
Maximal LVWT (mm)#	26.0 (6.9)	17.9 (8.3)	0.861 (0.735–1.009)	0.064
LA diameter (mm)#	47.0 (9.0)	50.0 (8.5)	1.011 (0.924–1.107)	0.811
LVOT gradient pressure (mmHg)#	44.0 (57.0)	2.0 (25.9)	0.954 (0.917–0.992)	0.019*
SCD family history (N, %)	6, 22.2%	0, 0%	0.629 (0.077–5.121)	0.665
NSVT (N, %)	5, 18.5%	4, 80.0%	9.779 (1.953–48.964)	0.006*
Unexplained syncope (N, %)	13, 48.1%	2, 40.0%	0.630 (0.150–2.644)	0.528
Age (years)	43.0 ± 12.9	52.8 ± 9.3	1.046 (0.990–1.105)	0.106
Maximal LVWT ≥30 mm (N, %)	11, 40.7%	1, 20.0%	0.381 (0.098–2.426)	0.381
LGE/LV mass ≥15% (N, %)	19, 70.4%	4, 80.0%	2.981 (0.366–24.273)	0.307
End-stage systolic dysfunction (N, %)	1, 3.7%	2, 40.0%	13.104 (2.546–67.440)	0.002*
Cardiac MRI mapping parameters$
Global native T1 (ms)+	1,318.6 ± 43.2	1,358.3 ± 50.6	1.741 (1.038–2.921)	0.036*
Increased global native T1 (N, %)	17, 70.8%	7, 87.5%	3.634 (0.433–30.517)	0.235
Minimal native T1 (ms)+	1,243.0 ± 56.7	1,269.8 ± 41.6	1.308 (0.887–1.930)	0.175
Maximal native T1 (ms)+	1,375.6 ± 51.4	1,435.5 ± 83.9	1.409 (1.058–1.875)	0.019*
Global ECV (%)+	31.0 ± 3.9	38.9 ± 10.6	1.236 (1.059–1.442)	0.007*
Increased global ECV (N, %)	15, 62.5%	6, 75.0%	1.728 (0.347–8.596)	0.504
Minimal ECV (%)+	25.4 ± 2.7	27.2 ± 4.6	1.333 (0.875–2.030)	0.180
Maximal ECV (%)+	37.0 ± 7.5	51.3 ± 16.4	1.150 (1.044–1.267)	0.005*
Multivariate cox regression analysis
NSVT	–	–	9.779 (1.953–48.964)	0.006*

SCD, sudden cardiac death; MACE, major adverse cardiovascular events; HR, hazard ratio; CI, confidence interval; ECV, extracellular volume fraction.

⁺Expressed as mean ± standard deviation.

^#Expressed as median (interquartile range).

^$Native T1 values were set as per SD (30 ms) increase; ECV values were set as per SD (2%) increase.

^*statistically significant difference.