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. 2021 Jun 8;15:664641. doi: 10.3389/fnins.2021.664641

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Copyright © 2021 Xu, Wang, Cao, Li, Zhou, Ren and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Surgical trauma and anesthesia and fecal microbiota transplantation exacerbated neurobehavioral impairment on postoperative or post-transplantation day 3 in the open-field test. Treatment with SCFAs significantly improved behavioral performance on postoperative day 3. (A) The time spent in the center area. (B) Total distance moved in the center. The results are represented as mean ± SEM. *p < 0.05 vs. the day-matched control group, **p < 0.001 vs. the day-matched control group, ^#p < 0.05 vs. the day-matched surgery group. P3 and P7: postoperative or post-transplantation days 3 and 7, respectively.