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. 2021 Jun 8;15:664641. doi: 10.3389/fnins.2021.664641

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Copyright © 2021 Xu, Wang, Cao, Li, Zhou, Ren and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Surgical trauma and anesthesia and fecal microbiota transplantation significantly enhanced hippocampal IL-6 expression on postoperative or post-transplantation day 3 compared with the control group. Pretreatment with SCFAs partially reversed the higher expression of IL-6. The effects of SCFAs pretreatment for reversed IL-6 expression was maintained until day 7 compared with that of the surgery group. (A) The level of hippocampal IL-6 on postoperative or post-transplantation day 3. (B) The level of hippocampal IL-6 on postoperative or post-transplantation day 7. The results are represented as mean ± SEM. **p < 0.001 vs. the day-matched control group, ^#p < 0.05 vs. the day-matched surgery group, ^##p < 0.001 vs. the day-matched surgery group. P3 and P7: postoperative or post-transplantation days 3 and 7, respectively.