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. 2021 Jun 8;15:605030. doi: 10.3389/fncel.2021.605030

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Copyright © 2021 Iwasa, Matsui, Iguchi, Kinugawa, Morikawa, Sakaguchi, Shiota, Kobashigawa, Nakanishi, Matsubayashi, Nagata, Kikuchi, Tanaka, Eura, Kiriyama, Izumi, Saito, Kataoka, Saito, Kimura, Wanaka, Nishimura, Mori and Sugie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) In human cerebral organoids (hCO), expression of hypoxic marker genes; PKM2, VEGFA, and HIF1A after OGD/R. The P-value of PKM2 was 0.0054. **P < 0.001 vs. ctrl. (B) After OGD/R, expression level of PKM2 and Pkm2 were validated using human cerebral organoids, mouse embryonic cortical neuron (mECN), hepatocellular carcinoma (HepG2), telomerase reverse transcriptase immortalized fibroblasts (hTERT-BJ), and glioblastoma (U251MG). (C) After OGD/R, expression level of VEGFA and Vegfa were validated using human cerebral organoid, mECN, HepG2, hTERT-BJ, and U251MG. The P-values were 0.0457 (BV2), 0.0030 (BJ), and < 0.0001 (U251MG). *P < 0.05, **P < 0.001, ***P < 0.0001 vs. ctrl.