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. 2021 Jun 8;13:651638. doi: 10.3389/fnagi.2021.651638

FIGURE 3.

FIGURE 3

(A) Open field test to measure volitional locomotion. Male Map2k5+/– mice displayed a decreased total distance compared with WT mice in traveled in open field test (P = 0.004, n = 4). (B) Rotarod test. Female Map2k5+/– mice have impaired coordination ability in rounds 2 and 3 (P1 = 0.157, P2 = 0.036, P3 = 0.003, n = 4). (C–F) Total activity (TOT) and ambulatory activity (AMB) with 12 h (light)–12 h (dark) cycle in both male (C,E) and female mice (D,F). AMB and TOT were decreased significantly in female Map2k5+/– mice during their light phase (rest phase) (n = 8). (G,H) Acoustic startle response (ASR) and prepulse inhibition (PPI) of WT and Map2k5+/– mutant mice. (G) ASR increased in male Map2k5+/– mutant mice at 78, 84, 90, and 120 dB (P = 0.035, 0.029, 0.006, and 0.019, respectively). (H) Prepulse inhibition (PPI) was decreased in male Map2k5+/– mutant mice at 90 dB (P = 0.024, n = 6). Results are plotted as mean with SEM. Bars represent means with SEM. *P < 0.05, **P < 0.01.