TABLE 1.

Levels of phenylalanine (Phe), tyrosine (Tyr), dopamine (DA), epinephrine (Epi), serotonin, and its metabolite 5-HIAA in the striatum.

Neurochemicals	WT	Map2k5+/–	P-value
Phe	26.46 ± 1.17	34.04 ± 1.01	0.001**
Tyr	29.62 ± 2.24	35.95 ± 1.01	0.033*
DA	1.55 ± 0.59	1.34 ± 0.63	0.815
Epi	1.50 ± 0.62	1.07 ± 0.46	0.621
Gln	675.43 ± 189.03	574.01 ± 163.44	0.695
ACh	0.58 ± 0.17	0.22 ± 0.07	0.094
Serotonin	0.04 ± 0.00	0.03 ± 0.02	0.743
5-HIAA	0.35 ± 0.11	0.26 ± 0.05	0.478

The values of neurochemicals are represented in means ± SEM (μg/g) of the tissue (t-test, n = 5). *P < 0.05, **P < 0.01.