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. 2021 Jun 21;11:12924. doi: 10.1038/s41598-021-92345-2

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© The Author(s) 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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IHZ attenuates insulin resistance in HF with low STZ induced diabetic rats. Rats were fed with High Fructose (HF, 20%) water for 6 weeks and single dose of STZ (35 mg/kg, i.p.) was administered at the end of 5th week, with or without IHZ (25 mg/kg, p.o.) for 6 weeks. Analysis of body weight was done every week and biochemical parameters were carried out in plasma on 0, 14, 35 and 42 days from different animal groups. (a) Change in weight of animals during the study period. (b) Change in plasma cholesterol levels as measured using commercial kit over the course of the study on specified days. (c) Change in plasma glucose levels measured by glucometer on specified days. (d) Levels of low density Lipids (LDL) measured with commercial kit. Data is presented as mean ± SD of n = 6 animals for each group. ***P < 0.001 vs control group; %P < 0.05, %%%P < 0.001 vs HF + STZ group.