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. 2021 Jun 21;11:12927. doi: 10.1038/s41598-021-92371-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Microscale simulation for 5 ROIs. (A) The location of regions of interest. These regions of interest are in the ipsilateral hemisphere of the brain (cortex and corpus callosum) below the impact where the model predicts the highest strain and shear stress (Fig. 1), (B) the magnified view of the vessels within the regions of interest, (C) vessels’ axial stress as a function of time and the angle between the vessels and the direction of the 1st principal stress of the neighbouring tissue. Vessels axial stress raises as the time passes and as the angle between the vessel and direction of 1st principal stress of the vessels’ neighbouring tissue goes towards zero. (D) Linear regression between the logarithm of the vessels’ axial stress and the angle between the vessels and the direction of the 1st principal stress. (E) Linear regression between the vessels’ axial stress and the angle between the vessels and the direction of the 1st principal strain.