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. 2021 Jun 21;12:3803. doi: 10.1038/s41467-021-23501-5

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© The Author(s) 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a The correlation between the mRNA levels of METTL3 and APC in ESCC of TCGA was analysed by the two-tailed Pearson correlation coefficient. b The relative mRNA expression levels of APC were analysed in 119 paired ESCC tissues and their adjacent normal tissues (from the GSE53625 dataset). Data represent the means ± SD of 119 samples. ***p = 1.75E − 15 based on two-tailed and paired Student’s t-test. c IHC staining of 81 ESCC specimens was performed with the indicated antibodies three times with similar results. Representative images of METTL3, APC and β-catenin expression levels in two cases of ESCC are shown. Scale bar, 100 μm. d The correlation between the expression levels of METTL3 and APC in 81 ESCC specimens was analysed by the two-tailed Pearson correlation coefficient. p < 0.0001. e The correlation between the expression levels of METTL3 and β-catenin in 81 ESCC specimens was analysed by the two-tailed Pearson correlation coefficient. p < 0.0001. f Kaplan–Meier plots of the overall survival rates of human ESCC patients (n = 81) with high and low expression of APC. p-Values were calculated using the two-tailed log-rank test. Source data are provided as a Source Data file.