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. 2021 Jun 21;11:12973. doi: 10.1038/s41598-021-92332-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of both screens and secondary analysis of high confidence hits. (a) A second screen targeting a subset of genes (831 genes with FDR ≤ 0.2) was performed at very high cell-to-guide coverage (36,000×). 75 genes were detected with FDR ≤ 0.1 in both screens. One gene from the first screen showed an opposite effect in the 2nd screen and was excluded. (b) Beta values of the second screen are compared to the beta values of the first screen. (c) Depicted are enriched canonical pathways from IPA with − log(p values) of ≥ 5. The z score is color coded; positive and negative values indicate inhibition and activation of phagocytosis, respectively.