Table 4.

Univariate and multivariate analyses of factors associated with early extrahepatic recurrence.

	Univariate analysis		Multivariate analysis
	HR (95% CI)	p-value	HR (95% CI)	p-value
Serum ALP > 120 U/L	2.790 (1.279–6.084)	0.010	2.362 (1.018–5.478)	0.045
Pathologic mUICC stage (III, IVa)	3.418 (1.634–7.151)	0.001	2.610 (1.154–5.901)	0.021
Worst Edmonson Steiner grade ≥ 4	2.221 (1.063–4.643)	0.034
Surgical margin involvement	2.991 (1.043–8.576)	0.041	4.035 (1.280–12.725)	0.017
Venous/lymphatic involvement	1.890 (0.925–3.860)	0.081
Absence of fatty change	3.582 (1.249–10.276)	0.018	3.246 (1.114–9.461)	0.031
Sum of tumor size > 7 cm	2.142 (1.055–4.347)	0.035
Macrovascular invasion	3.818 (1.559–9.351)	0.003	3.207 (1.169–8.799)	0.024

HR hazards ratio, CI confidence interval, ALP alkaline phosphatase, mUICC modified Union for International Cancer Control, AFP alpha-fetoprotein.