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. 2021 Jun 8;8:687113. doi: 10.3389/fmolb.2021.687113

FIGURE 4.

FIGURE 4

Overexpression of lncRNA MEF2C-AS1 inhibited proliferation, migration and invasion of CC cells by regulating miR-592. (A) Expression of miR-592 after transfection of pc-MEF2C-AS1, miR-592 mimics or pc-MEF2C-AS1 + miR-592 mimics was detected by qRT-PCR; (B) The proliferation ability of SiHa and HeLa after transfected with pc-MEF2C-AS1, miR-592 mimics or pc-MEF2C-AS1 + miR-592 mimics was measured by CCK-8; (C) The colony formation ability of SiHa and HeLa after transfected with pc-MEF2C-AS1, miR-592 mimics or pc-MEF2C-AS1 + miR-592 mimics was measured by colony formation assay; (D) After transfected with pc-MEF2C-AS1, miR-592 mimics or pc-MEF2C-AS1 + miR-592 mimics, transwell assay was conducted to detect the migration ability of SiHa and HeLa; (E) After transfected with pc-MEF2C-AS1, miR-592 mimics or pc-MEF2C-AS1 + miR-592 mimics, transwell assay was performed to measure the invasion of SiHa and HeLa. Measurement data were expressed as mean ± standard deviation. The cell experiment is repeated three times independently. **p < 0.01, compared with pc-NC + mimics NC group; ## p < 0.01, compared with pc-MEF2C-AS1 + mimics NC or pc-NC + miR-592 mimics group (A–E).