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. 2021 Jun 8;8:687113. doi: 10.3389/fmolb.2021.687113

FIGURE 6.

FIGURE 6

Low expression of miR-592 inhibited proliferation, migration and invasion of CC cells by regulating RSPO1. (A) Expression of miR-592 after transfection of miR-592 inhibitor, si-RSPO1 or miR-592 inhibitor + si-RSPO1 was detected by qRT-PCR; (B) The proliferation ability of SiHa and HeLa after transfected with miR-592 inhibitor, si-RSPO1 or miR-592 inhibitor + si-RSPO1 was detected by CCK-8; (C) The colony formation ability of SiHa and HeLa after transfected with miR-592 inhibitor, si-RSPO1 or miR-592 inhibitor + si-RSPO1 was measured by colony formation assay; (D) The migration ability of SiHa and HeLa after transfected with miR-592 inhibitor, si-RSPO1 or miR-592 inhibitor + si-RSPO1 was detected by using transwell assay; (E) The invasion ability of SiHa and HeLa after transfected with miR-592 inhibitor, si-RSPO1 or miR-592 inhibitor + si-RSPO1 was detected by using transwell assay. Measurement data were expressed as mean ± standard deviation. The cell experiment is repeated three times independently. **p < 0.01, compared with inhibitor NC + si-NC group; ## p < 0.01, compared with miR-592 inhibitor + si-NC or inhibitor NC + si-RSPO1 group (A–E).