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. 2021 Jun 8;9:691585. doi: 10.3389/fcell.2021.691585

FIGURE 1.

FIGURE 1

Summary of AMP-activated protein kinase (AMPK) structure and activation. Domain structure of AMPK trimer: α-, β-, and γ-subunits with respective domains. AMPK α subunits: KD, kinase domain containing Thr-172 phosphorylation site; AID, autoinhibitory domain; BD, binding domain. AMPK β subunits: CBM, carbohydrate binding module; BD, binding domain. AMPK γ subunits: CBS, cystathione-β-synthase domain. The upstream kinases LKB1, CAMKK2, and TAK1 are shown above the AMPK complex. LKB1 in complex with STRAD and MO25 activates AMPK; CAMKK2 activated by intracellular calcium.