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. 2021 Jun 8;9:643060. doi: 10.3389/fcell.2021.643060

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Copyright © 2021 Schaberg, Theocharidis, May, Lessmann, Schroeder and Faissner.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Suppression of sulfation lengthened the cell cycle in the presence of FGF2. Cell cycle lengths of control (black boxes) versus chlorate-treated (gray boxes) spinal cord progenitors maintained in the presence of FGF2 were compared. The cells from the first generation (A) were captured at different starting points of their division cycle and could only be tracked for an undefined portion of the running cell cycle. From the second generation (B) on the cell cycle lengths could be compared statistically. The inhibition of sulfation led to a slower cell division of progenitors treated with chlorate. The prolongation of the cell cycle was particularly striking between the 3rd up to the 5th round of division (C–E). The sixth generation (F) was only traceable for a few cells (compare to the lineage tree in Figure 4E) ***p ≤ 0.001 (Mann–Whitney U-test); con: N = 4; chlorate: N = 3.