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. 2021 Jun 8;12:686273. doi: 10.3389/fimmu.2021.686273

Figure 1.

Figure 1

Frequencies of total B-cells and B-cell subsets in patients with axSpA, pSS and healthy donors. Global gating strategy is shown with arrows pointing towards the next level of gating. Frequencies of (A) total B-cells (CD19+), relative to total lymphocytes, and the following B-cell subsets, relative to total B-cells, are shown: (B) memory B-cells (CD27+IgD-), (C) double negative (CD27-IgD-) B-cells, (D) naïve (CD27-IgD+) B-cells, (E) plasmablasts (CD27+CD38hi), (F) transitional (CD24hiCD38high) B-cells, (G) CD27+CD38lowCD21low B-cells and (H) CD27-CD38lowCD21low B-cells. Patients with axial spondyloarthritis (axSpA; n = 45) are indicated with red circles, healthy donors (HD; n = 30) are indicated with green squares and patients with primary Sjögren’s Syndrome (pSS; n = 20) are indicated with blue triangles. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, ns, not significant and horizontal lines indicate the medians.