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. 2021 Jun 8;12:686273. doi: 10.3389/fimmu.2021.686273

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Copyright © 2021 Wilbrink, Spoorenberg, Arends, van der Geest, Brouwer, Bootsma, Kroese and Verstappen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Distribution of immunoglobulins IgD and IgM by CD27CD38^lowCD21 B-cell compartment in patients with axSpA, pSS and HDs. Analysis of the distribution of immunoglobulins IgD and IgM (A) is shown for CD27⁺CD38^lowCD21^low, CD27⁺CD38^lowCD21⁺, CD27^-CD38^lowCD21^low, CD27^-CD38^lowCD21⁺ B-cells respectively. A more detailed analysis of the immune marker expression (B) by the naïve (IgD⁺IgM⁺) in orange and switched (IgD^-IgM^-) B-cell populations in blue shown as histogram plots comparing CD27^-CD38^lowCD21^low B-cell populations of one axial spondyloarthritis patient, one primary Sjögren’s syndrome patient and a healthy donor. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, ns, not significant and horizontal lines indicate the medians.