Figure 4.

Relationship between frequencies of CD27^-CD38^lowCD21^low B-cells and clinical parameters in patients with axSpA. (A) Patients with axial spondyloarthritis (axSpA) were divided into separate groups based on subcategories of axSpA and the following clinical parameters: Biological DMARD naïve, nr-axSpA or axSpA, sex, symptom duration, C-reactive protein (CRP) and Ankylosing Spondylitis Disease Activity Score (ASDAS). (B) To explore associations between the CD27^-CD38^lowCD21^low B-cell compartment and several continuous clinical parameters in patients with axSpA, the frequency of CD27^-CD38^lowCD21^low B-cells was plotted against the following clinical parameters: Age, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), ASDAS, CRP, erythrocyte sedimentation rate (ESR), symptom duration. Patients with axSpA(n=45) are indicated with red circles, healthy donors (HD; n = 30) are indicated with green squares. *P < 0.05, **P < 0.01, ****P < 0.0001, significant values in bold, ns, not significant and horizontal lines indicate the medians.