Table E3.
Refresh Tears skin testing results on nonallergic, clinically tolerant controls, reflecting a high frequency of false-positive, irritant reactions
| Patient | Refresh Tears 1:100 (intradermal), mm (wheal flare) | Refresh Tears 1:10 (intradermal), mm (wheal ×flare) |
|---|---|---|
| 1 | 10 × 20 | — |
| 2 | 0 | 7 × 15 |
| 3 | 0 | 8 × 18 |
| 4 | 0 | 0 |
| 5 | 8 × 18 | — |
| 6 | 9 × 14 | — |
| 7 | 0 | 0 |
| 8 | 0 | 0 |
| 9 | 0 | 0 |
| 10 | 0 | 0 |
| 11 | 8 × 13 | — |
| 12 | 0 | 0 |
| 13 | 9 × 20 | — |
| 14 | 0 | 7 × 18 |
| 15 | 0 | 0 |
| 16 | 0 | — |
| 17 | 0 | — |
| 18 | 0 | 6 × 24 |
| 19 | 0 | 0 |
| 20 | 0 | 0 |
| 21 | 0 | 0 |
| 22 | 8 × 18 | — |
| 23 | 7 × 8 | — |
| 24 | 0 | 4 × 8 |
| 25 | 5 × 10 | — |
| Total | 8 (32%) | 5 (20%) |
Among 25 nonallergic controls, there were 13 positive reactions (52%) to Refresh Tears on intradermal testing, with 8 positive at the 1:100 concentration (32%) and 5 positive at the 1:10 concentration (20%).