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. 2021 Jun 8;11:665045. doi: 10.3389/fonc.2021.665045

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Copyright © 2021 Wang, Xia, Chen, Chen, Meng, Lv and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of PHLPP suppression on EGFR-TKI sensitivity in vivo. (A, B). Xenografts in nu/nu mice were generated from either HCC827-shControl (A) or HCC827-shPHLPP cells (B). Gefitinib (150mg/kg) was administered by oral gavage, and tumors volume were measured every other day. Mean tumor volumes were shown. (C) The mean residue tumor volume after 21-day course gefitinib treatment statistical testing was performed by two-sided t-test; ***P < 0.0005. (D) The log fold and absolute fold change of PHLPP mRNA from a previously study have been published from Zhang et al.