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. 2021 Jun 16;17:1953–1963. doi: 10.2147/NDT.S311429

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© 2021 Hung et al.

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ROC analysis results. The arrow points to the cutoff value for TRADE scores larger than 4.5 (considered difficult-to-treat) while the true condition is indicated at 12.5 months. Patients with TRADES scores larger than 4.5 and the final switch in prescribed antidepressant medication between different pharmacological class occurring later than 12.5 months were predicted to be unstable/difficult-to-treat.