TABLE 2.

Rikkunshito ingredients with a ghrelin-related effect.

Herb	Ingredient	Target	Role	References
Poria sclerotium	Pachymic acid		Inhibit ghrelin degration	Sadakane et al. (2011)
Citrus unshu Peel	Heptamethoxyflavone	PDEIII	Improve ghrelin resistance	Takeda et al. (2010)
	Nobiletin	PDEIII	Improve ghrelin resistance	Takeda et al. (2010)
	Isoliquiritigenin	PDEIII	Improve ghrelin resistance	Takeda et al. (2010)
	Hesperidin	5-HT(2C)R	Promote ghrelin secretion	Nahata et al. (2013)
Ginger	8-Gingerol	5-HT(2C)R	Promote ghrelin sectertion	Nahata et al. (2013)
	10-Gingerol		Inhibit ghrelin degration	Sadakane et al. (2011)
Glycyrrhiza	Isoliquiritigenin	5-HT(2B)R	Promote ghrelin secretion	Yamada et al. (2013)
Atractylodes lancea Rhizome	Atractylodin		Promote ghrelin secretion	Fujitsuka et al. (2011)

PDE III, phosphodiesterase III; 5-hydroxytryptamine 2C receptor, 5-HT(2C)R, 5-hydroxytryptamine 2B receptor, 5-HT(2B)R.