Fig. 3.

Optimal profile for a patient with normal renal function. Dose optimization for patients with normal renal function (creatinine clearance = 80 mL/min) after an administration every 8 h (a), 12 h (c) and 24 h (e). CMS in the central (dotted line) and peripheral (light gray line) compartments and colistin plasma concentrations (dark gray line) over time for a regimen with administration every 8 h (b) 12 h (d) and 24 h (f). γ: Standard deviation from target concentration 2 mg/L; CMS: colistimethate sodium; MIU: million international units