Fig. 4.

Optimal profile for patients with different renal conditions. Dose optimization for patients with creatinine clearance equal to 20 mL/min (black bar) 80 mL/min (white bar) and 150 mL/min (gray bar) after an administration every 8 h (a), 12 h (c) and 24 h (e). Colistin plasma concentrations over time for patients with creatinine clearance equal to 20 mL/min (dotted line) 80 mL/min (light gray line) and 150 mL/min (black line) for a regimen with administrations every 8 h (b) 12 h (d) and 24 h (f). CrCL: creatinine clearance; γ: Standard deviation from target concentration 2 mg/L; CMS: colistimethate sodium; MIU: million international units