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. 2021 Jun 21;18:140. doi: 10.1186/s12974-021-02183-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Gene expression profile indicates neuroinflammatory changed in mice fed HFD. A A custom panel of 30 genes critical for hypothalamic function was included and several genes highlighted. B, C Highly regulated genes from the 770 gene off-the-shelf neuroinflammation panel are highlighted from the posterior sections (B) and anterior sections (C). The panel contains 7 housekeeping genes used for normalization and 8 genes to determine lower limit. The data analysis was performed using nSolver Analysis Software 4.0 and nCounter Advanced Analysis. Data were plotted as log fold change on x-axis vs. log p value on y-axis. Red indicates genes that increase with HFD compared to control fed mice, while green indicates genes that decease with HFD compared to controls